Clinical Trials

Psychedelic-Assisted Clinical Trials at Pacific Neuroscience Institute

Our clinical trials work at TRIP is aiming to help develop novel psychedelic therapies and advance psychedelic medicines including psilocybin, LSD derivatives, 5-MeO-DMT and MDMA towards FDA approval.  

We will continue conducting clinical trials for conditions such as depression, anxiety, addiction and grief. In the future, we plan to expand our focus to trials in patients with brain injury and neurodegenerative conditions such as traumatic brain injury (TBI), stroke, mild cognitive impairment, dementia, and pain syndromes. It is in these areas where the neuroplasticity-promoting effects of psychedelics may be “game-changers” in helping to restore cognitive function, halt further deterioration and ultimately improve quality of life.   

Clinic: 1301 20^th St #540, Santa Monica, CA 90404

Open Trial

ClinicalTrials.gov

Recruiting

Postpartum Depression (PPD)

A Multicenter, Randomized, Double-Blind, Parallel-Group Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Patients with Postpartum Depression (PPD)
Sponsor: Reunion Neuroscience | PNI research team: 424-238-0763

Completed Trials

Completed Trial

Generalized Anxiety Disorder

A Dose-Finding Study of MM-120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms:
Multi-site trial. Completed enrollment of 15 patients. Sponsor: MindMed

ClinicalTrials.Gov

Completed Trial

Major Depressive Disorder

Psilocybin for Major Depressive Disorder Phase 2 Trial:
Completed enrollment of 5 patients as a site in this multi-site trial (PSIL201) and completed all study close-out activities. Sponsor: Usona

ClinicalTrials.Gov

Completed Trial

Alcohol Use Disorder

Visual Healing (Investigator-Initiated Trial):
Pilot Trial of a nature-themed video intervention to optimize set and setting for psilocybin therapy for alcohol use disorder. Completed enrollment of 20 patients.

Start Up Phase Trials

Start Up Phase

Brain Tumor Distress

Pilot trial of psilocybin-assisted therapy for psychiatric distress in patients with brain tumors (Investigator-Initiated Trial):
To assess feasibility and safety of psilocybin-assisted therapy in patients with brain tumors. Enrollment Winter 2023

ClinicalTrials.Gov

Start Up Phase

Treatment-Resistant Depression

Phase 2b Study to Evaluate the Efficacy and Safety of Intranasal BPL-003, a novel synthetic formulation of 5-MeO-DMT (Mebufotenin) in Patients with Treatment-Resistant Depression:
Multi-site clinical trial with enrollment Winter 2023. Sponsor: Beckley Psytech

Videos about Psychedelic-Assisted Therapy

Meet Dr. Heinzerling Dr. Heinzerling is the Director, Pacific Treatment & Research In Psychedelics Program; Internal Medicine – Addiction Medicine, Brain Health Center. He practices internal medicine and is an addiction medicine specialist… Psychedelic-Assisted Therapy at Pacific Neuroscience Institute Dr. Keith Heinzerling is an addiction medicine specialist and Director of Treatment & Research In Psychedelics (TRIP) at Pacific Neuroscience Institute in Santa Monica, CA. Learn about how psychedelic-assisted therapy… Helping Patients and Advancing Science With a Psilocybin Trial | Karina Sergi, MS, MFT 39. A Life-Changing Clinical Trial with Psychedelics | Vikki’s Grateful Patient Story Vikki was walking her dog and listening to NPR in Santa Monica one day, when she heard an advertisement for an unusual medical trial. Pacific Neuroscience Institute was studying whether… Think Neuro Podcast: The Promise of Psychedelics | Dr. Keith Heinzerling & Louie Schwartzberg Addiction and depression are two of the most widespread conditions in all of medicine. After decades of research, doctors are still looking for alternatives for when medication and cognitive training… Healing with Visual Art, Music & Mushrooms with Louie Schwartzberg (ft. Deepak Chopra & Dr. Dan Kelly) https://fungiglobalsummit.com/ Voices from the Underground is The Deep Dive, Intimate Conversations with Thought Leaders & Fungi Experts hosted by Louie Schwartzberg. Get Premium Access and join Louie as he digs… Brain Injuries and Psychedelics Ian McCall is a former professional MMA fighter who suffered from symptoms of traumatic brain injuries. After retirement, McCall experienced confusion, anger issues, depression, and suicidal ideation. Feeling hopeless, he… Psychedelics Renaissance | Dr. Daniel Kelly Dr. Dan Kelly is the director and one of the four co founders of the Pacific Neuroscience Institute, a multispecialty group of over 35 physicians working across nine centers of… Treatment & Research In Psychedelics (TRIP) at Pacific Neuroscience Institute | Explainer At PNI’s Treatment & Research In Psychedelics (TRIP) Program, we conduct clinical trails at the forefront of innovative and transformative medicine. TRIP, spearheaded by Daniel Kelly, MD and Keith Heinzerling,… NBC News Features Treatment & Research In Psychedelics (TRIP) at PNI NBC News features Pacific Neuroscience Institute’s Dr. Daniel Kelly & Dr. Keith Heinzerling, and filmmaker Louie Schwartzberg, and PNI’s groundbreaking psychedelic-assisted clinical trial for alcohol use disorder which launched in… Psychedelic-Assisted Therapy: A New Dawn for Mental Health | Daniel Kelly, MD Adapted from lecture at Claremont McKenna College Thu, September 16, 2021 Alum, Daniel Kelly, M.D. ’82, a neurosurgeon and neuroscientist, discusses the history, current state and future opportunities of psychedelic-assisted…

Meet Dr. Heinzerling

Psychedelic-Assisted Therapy at Pacific Neuroscience Institute

Helping Patients and Advancing Science With a Psilocybin Trial | Karina Sergi, MS, MFT

39. A Life-Changing Clinical Trial with Psychedelics | Vikki’s Grateful Patient Story

The Promise of Psychedelics | Dr. Keith Heinzerling & Louie Schwartzberg

Healing with Visual Art, Music & Mushrooms with Louie Schwartzberg (ft. Deepak Chopra & Dr. Dan Kelly) | Fungi Global Summit

Brain Injuries and Psychedelics

Psychedelics Renaissance | Dr. Daniel Kelly

Treatment & Research In Psychedelics (TRIP) at Pacific Neuroscience Institute | Explainer

NBC News Features Treatment & Research In Psychedelics (TRIP) Program at PNI

Psychedelic-Assisted Therapy: A New Dawn for Mental Health | Daniel Kelly, MD

Articles about psychedelic-assisted therapy

Amelia Garrison

Vikki’s Path to Sobriety at the Treatment & Research In Psychedelics (TRIP) Program

After years of unsuccessful therapy, Vikki transformed her life for the better with psychedelic-assisted therapy at PNI’s Pacific Treatment & Research In Psychedelics (TRIP). Learn more about her journey toward healing.

Guest Author

Psilocybin and the TRIP Program at Pacific Neuroscience Institute

A growing body of research now supports the potential use of mushrooms containing the chemical psilocybin for a range of cognitive, mental and behavior disorders. Several research projects at Pacific Neuroscience Institute at Providence Saint John’s Health Center are aimed at determining the safety and…

PNI Experts

PNI Publishes First-Ever Paper on Psychedelics in Neurosurgery and Neuro-oncology Literature

After a decades-long pause, psychedelics are once again being investigated for their transdiagnostic treatment potential. Discover the future of psychedelics in neurosurgery and neuro-oncology with experts from Pacific Neuroscience Institute ® (PNI).

Is TRIP right for you?

For more information about treatment and research studies at the TRIP program please contact Dr. Heinzerling.

Virtual Video Visits Are Available
Our specialists have consultation openings for new patients anywhere in California.

Treatment with Ketamine: 310-582-7612
Clinical Trials: 310-582-7611

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